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Antibiotic treatment is the standard way to induce dysbiosis, characterized by four aspects: loss of critical taxa, loss of diversity, changes in metabolic activity, and development of a pathogenic microflora
Our study demonstrates that administration of broad-spectrum antibiotics in adolescent mice for two weeks resulted in higher mortality and lower weight gain and induced significant changes in behavior of animals including decreased locomotor and exploratory activity, reduced muscle strength, visceral hypersensitivity, increased anxiety and impaired cognitive functions.
These changes were accompanied by decreased diversity and total amount of bacteria, abundance of Proteobacteria and Verrucomicrobia phyla, and reduced Firmicutes/Bacteroides ratio in the gut microbiota.
Subsequently, this can lead to chronic inflammation, which is usually associated with higher energy consumption and a predisposition to growth and development disorders
see also:
Allergic reactions / Allergies & Gut microbiota
Antibiotics & Dysbiosis
Antibiotics & Gut microbiota
Dysbiosis
Asthma & Dysbiosis