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Chronic Liver Diseases

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The etiologies of chronic liver disease vary, such as infection by viruses or bacteria, alcohol or toxic substances, excessive accumulation of fat or heavy metals, and abnormal immune responses
Son et al. 2021 Life 11: 349

These causes can lead to viral hepatitis, nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), toxic hepatitis, and autoimmune liver disease. In addition, they can be aggravated by cirrhosis or liver cancer after a chronic course.
Eom et al. 2021 Int. J. Mol. Sci. 22: 6326

If liver damage repeatedly occurs due to any cause, there is a high risk of developing advanced liver disease regardless of the presence or absence of symptoms, and treatment once cirrhosis occurs is necessary
Moon et al. 2020 Clin. Gastroenterol. Hepatol. 18: 2650-2666