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In brief, AEA is biosynthesized from the hydrolysis of N-acyl-phosphatidylethanolamines (NAPE)) by NAPE-specific phospholipase D-like enzyme (NAPE-PLD) or via other routes not involving NAPE-PLD
Anandamide mimic several of the pharmacological properties exerted by the central active principle of cannabis, tetrahydrocannabinol (THC), both in vitro and in vivo
Anandamide activates [Cannabinoid…