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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Tumor-infiltrating lymphocytes (TILs)

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Cellular transformation induces phenotypically distinct populations of tumor-infiltrating T cells
Zheng et al. 2017a Cell 169: 1342–1356
Azizi et al. 2018 Cell 174(5): 1293–1308
Simoni et al. 2018 Nature 557: 575–579
Zhang et al. 2018g Nature 564: 268–272
Zheng et al. 2021c Science 374: 1462

CD8+ T cells in tumors predict better outcomes. They are key for Immune Checkpoint Inhibitors (ICIs) Therapy
Wang et al. 2021o Journal for ImmunoTherapy of Cancer 9: e003100

In addition, ILTCKs are also included
Dadi et al. 2016 Cell 164: 365–377

ILTCKs are alfa/beta T cell receptor (TCR)-positive FCER1G-expressing innate T …

References (Sources)

Bystander CD8 +T cells are abundant and phenotypically distinct in human tumour infiltrates
Simoni et al. 2018 Nature 557: 575–579
Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
Gajewski et al. 2013
Review
Identifying the source of tumour-infiltrating T cells
Kumar Vodnala & Restifo 2019
Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing
Zheng et al. 2017a Cell 169: 1342–1356
Single-cell map of diverse immune phenotypes in the breast tumor microenvironment
Azizi et al. 2018 Cell 174(5): 1293–1308
The Immune Contexture in Human Tumors: Impact on Clinical Outcome
Fridman et al. 2012
Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review
Nosho et al. 2010 J Pathol 222: 350-66
Review

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12/16/2025

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Tumor-infiltrating lymphocytes (TILs)

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