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The ASKHA superfamily is a group of enzymes involved in phosphoryl transfer reactions. It includes acetate and sugar kinases, heat shock cognate, and actin. The superfamily has undergone extensive divergent evolution, but it retains a two-domain structure containing duplicated core secondary structure elements and residues that bind the catalytic magnesium ion and the nucleotide alfa-phosphate
The ASKHA superfamily includes enzymes that catalyze the phosphorylation of various substrates, such as acetate, butyrate, and sugar kinases.
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