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CD152 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4))
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Contents
CD152 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4)) is an antigen on T cells that inhibits activated T cells, ending the immune response. Tumor cells often increase CTLA-4 to evade the immune system by stopping T cells prematurely.
CTLA-4 is upregulated upon T-cell activation
CTLA-4 interacts with CD80 and CD86
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) is not expressed by resting naive T cells, but becomes detectable 2 days after activation
Singh et al. 2013 Expert Opin. Bio…
References (Sources)
- Ipilimumab in Prostate Cancer
- Mechanisms and microbial influences on CTLA-4 and PD-1-based immunotherapy in the treatment of cancer: a narrative review
- The emerging role of CTLA4 as a cell-extrinsic regulator of T cell respons
- The perspective of immunotherapy: new molecules and new mechanisms of action in immune modulationReview
- The soluble isoform of CTLA-4 as a regulator of T-cell responses
- Tumor immunotherapy: Preclinical and clinical activity of anti-CTLA4 antibodiesReview
- VISTA Is a Novel Broad-Spectrum Negative Checkpoint Regulator for Cancer Immunotherapy