CD152 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4))

CD152 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4)) is an antigen on T cells that inhibits activated T cells, ending the immune response. Tumor cells often increase CTLA-4 to evade the immune system by stopping T cells prematurely (1). It is upregulated upon T-cell activation (2) and interacts with B7-1 and B7-2 by competing with the CD28 receptor (3). Engagement of Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) by the ligands B7-1 and B7-2 imparts a negative signal to T-cells and results in alteration of T-cell activity …