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CD152 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4)) is an antigen on T cells that inhibits activated T cells, ending the immune response. Tumor cells often increase CTLA-4 to evade the immune system by stopping T cells prematurely.
CTLA-4 is upregulated upon T-cell activation
CTLA-4 interacts with CD80 and CD86
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) is not expressed by resting naive T cells, but becomes detectable 2 days after activation
Singh et al. 2013 Expert Opin. Bio…