iNOS / Nitric Oxide Synthases (NOSs)

There are three isoforms of NOS, two of which - endothelial (eNOS) (Garthwaite et al. 1988 Nature 336: 385-388; Raman et al. 1998 Cell 95: 939-950) and neuronal (nNOS) (O’Dell et al. 1994 Science 265: 542-546; Iwai et al. 1995 Hypertension 25: 431-436; Bec et al. 1998 J. Biol. Chem. 273: 13502-13508) - are constitutively expressed, while the third one, inducible NOS (iNOS) (Geller et al. 1993 Proc. Natl. Acad. Sci. USA 90: 3491-3495; Geller et al. 1993a Proc. Natl. Acad. Sci. USA 90: 522-526; Hokari et al. 1994 J. Biochem. 116: 575-581), is expressed in response to cytokines and is related to inflammatory response the (Andrew & Mayer 1999 Cardiovasc. Res. 43: 521-531; Forstermann & Sessa 2012 Eur. Heart J. 33: 829-837, 837a-837d)
Gambardella et al. 2020 Biomedicines 8: 277

Host inflammation may influence microbiota composition through generation of specific metabolites such as Nitric Oxide Synthase (NOS2)
Sheflin et al. 2014 Curr Oncol Rep. 16(10): 406

Host Inflammation May Influence Microbiota Composition through Generation of Specific Metabolites Such as Nitric Oxide Synthase
Winter et al. 2013 Science 339(6120): 708-711