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Fiber supplementation plays a significant role in influencing gut microbiome composition and tryptophan catabolism, with effects varying depending on the colon segment. Notably, short-chain fatty acids (SCFAs) and inulin have been shown to prevent diet-induced obesity and insulin resistance in mice through distinct mechanisms, whereas [guar gum](brain://XUFZN3q3Z02Y5G7rOGkblg/Gu…