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Pregnane-X Receptors (PXRs) are found in the liver and gut. They help protect the body from harmful substances by increasing the production of Drug transporters and enzymes that break down drugs, specifically those in the cytochrome P450 family. These receptors are usually active on their own, but certain foreign substances can make them even more active. PXR is activated by many different pregnenolone derivatives, which are natural precursors for all steroid hormones. One example is 5beta-pregna…