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MHC class I-like molecules
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MHC class I-like molecules are a diverse group of proteins that share structural similarities with classical MHC class I / HLA class I human molecules but often have distinct functions in the immune system.
MHC class I-like molecules typically consist of a heavy chain with three extracellular domains (alfa1, alfa2, and alfa3) and a beta2-microglobulin light chain. They can be broadly classified into two categories:
- CD1 family: These molecules present lipid antigens to T cells.
- MHC Class I-Related Protein (MR1) and other [Non-classical MHC molecules](brain://jmp39_ALJEuxUMORCStvxw/NonclassicalMhcMo…