Lynch Syndrome / Hereditary nonpolyposis colorectal cancer

This type of colorectal cancer, which accounts for less than 5% of cases, arises from inherited mutations that greatly elevate the risk of developing the disease.
Mori & Pasca 2021

Lynch syndrome (LS) is the most common hereditary cancer syndrome. It accounts for approximately 3% of all colorectal cancers (CRCs).
Lynch et al. 2009 Clin Genet 76(1): 1-18
Buchanan et al. 2017 J Gastroenterol Hepatol 32(2): 427-438

The Lynch syndrome is the most common inherited syndrome associated with colorectal cancer and is also associated with extracolonic cancers. Confirmation of the diagnosis requires the detection of a germline mutation in a gene that causes deficient mismatch repair.
Giráldez et al.,…