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Mitochondrial pyruvate carrier (MPC) inhibitors

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Definition

Mitochondrial pyruvate carrier (MPC) inhibitors block the function of the Mitochondrial pyruvate carriers, a complex located in the inner mitochondrial membrane responsible for transporting pyruvate from the cytosol into the mitochondria.

Mitochondrial pyruvate carrier (MPC) inhibitors as drugs

Different classes of Mitochondrial pyruvate carrier (MPC) inhibitors show potential in treating metabolic disorders and their role in cancer metabolism.
Hodges et al. 2022 J Biol Chem. 298(2): 101554