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Tryptophan-derived microbial metabolites play multifaceted roles in health and disease. Many Tryptophan metabolites are thought to activate the aryl hydrocarbon receptor (AhR), regardless of their chemical properties. The activity of the Ah receptor can be predicted by metabolites derived from tryptophan in the intestinal microbiota (; ). This might be because the AhR ligand binding pocket is highly adaptable to different substrates. However, new evidence suggests that Tryptophan metabolites also interact with a range of other protein receptors beyond AhR. These include [G-protein coupled receptors (GPCRs)](brain://oVcbpD5M9U-UGTlns8LQNw/GproteinCoupledRec…