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Tryptophan metabolites
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Contents
Tryptophan-derived microbial metabolites play multifaceted roles in health and disease. Many Tryptophan metabolites are thought to activate the aryl hydrocarbon receptor (AhR), regardless of their chemical properties. The activity of the Ah receptor can be predicted by metabolites derived from tryptophan in the intestinal microbiota (; ). This might be because the AhR ligand binding pocket is highly adaptable to different substrates. However, new evidence suggests that Tryptophan metabolites also interact with a range of other protein receptors beyond AhR. These include [G-protein coupled receptors (GPCRs)](brain://oVcbpD5M9U-UGTlns8LQNw/GproteinCoupledRec…
References (Sources)
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- Enumeration of human colonic bacteria producing phenolic and indolic compounds: Effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism
- Indole and tryptophan metabolism: endogenous and dietary routes to Ah Receptor Activation
- Intestinal bacteria and the regulation of immune cell homeostasis.Review
- Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
- Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
- Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease