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Segatella copri is common in the human gut. It relates to health and disease. The factors for its gut colonization are unclear.
Segatella RNA colonization factor (SrcF) is key for S. copri in mice. SrcF regulates genes for nutrient uptake. Fructans influence its expression. Other gut bacteria break down fructans. This affects interspecies communication beyond energy production.
El Mouali et al. 2024 Cell Host & Microbe 32: 1910–926
High Segatella copri levels link to lower IBS risk. It associates w…