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Arginase-2
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Contents
Arginase-2 (ARG2) is one of two mammalian arginase isoforms. It is a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. Arginase-2 is a mitochondrial enzyme involved in arginine metabolism, with important roles in regulating nitric oxide production, immune cell function, and inflammation. Its activity is critical in extra-hepatic tissues, especially the kidney, and it is a key player in the resolution of inflammation, making it a significant target for research in immunology, neurology, a…
References (Sources)
- Arginase 2 Deficiency Promotes Neuroinflammation and Pain Behaviors Following Nerve Injury in Mice
- Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
- Mitochondrial arginase-2 is a cell-autonomous regulator of CD8+ T cell function and antitumor efficacy
- Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages