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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Butyrate / Butyric acid & Glucagon Like Peptide 1 (GLP-1)

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Butyrate and propionate stimulate the secretion of glucagon-like peptide 1 (GLP-1) and plasma peptide YY (PYY).

Butyrate directly stimulates the secretion of Glucagon Like Peptide 1 (GLP-1) from intestinal L-cells. This occurs through the activation of GPR43. The activation of these receptors leads to an increase in GL…

References (Sources)

Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion
Yadav et al. 2013 J Biol Chem 288(35): 25088-25097
Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents
Zhou et al. 2008 Am J Physiol Endocrinol Metab 295(5): E1160-6
SCFAs-Induced GLP-1 Secretion Links the Regulation of Gut Microbiome on Hepatic Lipogenesis in Chickens
Zhang et al. 2019 Front Microbiol 10: 2176
Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression
Zhou et al. 2018 Exp Mol Med 50(12): 1-12

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5/29/2026

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Butyrate / Butyric acid & Glucagon Like Peptide 1 (GLP-1)

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