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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Trimethylamine-N-Oxide (TMAO)

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Contents

Trimethylamine-N-oxide (TMAO) is a metabolite generated by the gut microbiota from dietary precursors such as phosphatidylcholine, choline, betaine, and L-carnitine, which are abundant in animal-based foods like red meat, fish, poultry, and eggs
Tang et al. 2013 N Engl J Med 368: 1575-84
Liu & Dai 2020 Mediat. Inﬂamm. 2020: 4634172
Gabbianelli & Bordoni 2022 In: Patel, V.B., Preedy, V.R. (eds) Biomarkers in Nutrition . Biomarkers in Disease: Methods, Discove…

References (Sources)

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
Tang et al. 2013 N Engl J Med 368: 1575-84
Long-term changes in gut microbial metabolite trimethylamine N-Oxide and coronary heart disease risk
Heianza et al. 2020 J. Am. Coll. Cardiol. 75: 763-772
Plasma trimethylamine N-Oxide and risk of cardiovascular events in patients with type 2 diabetes
Croyal et al. 2020 The Journal of Clinical Endocrinology & Metabolism 105(7): 2371-2380
Serum trimethylamine-N-oxide is strongly related to renal function and predicts outcome in chronic kidney disease
Missailidis et al. 2016 PLoS ONE 11, e0141738
The Accumulation and Molecular Effects of Trimethylamine N-Oxide on Metabolic Tissues: It’s Not All Bad
Krueger et al. 2021 Nutrients 13: 2873
Review
Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB
Seldin et al. 2016 J Am Heart Assoc. 5: e002767
Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
Ding et al. 2018 Lipids Health Dis. 17: 286

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Trimethylamine N-oxide - Wikipedia
https://doi.org/10.1007/978-3-030-81304-8_2-1