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Immune responses to foreign and self-antigens require specific and balanced responses to clear pathogens and tumors and yet maintain tolerance.
The selectivity of the immune response is dictated by sensors that recognize the stimulus, by the downstream signaling pathways, and by the transcriptional and chromatin regulators activated by these pathways.
A well-balanced immune response is crucial for the health and survival of an organism. When the immune system becomes overly active and [pro-infla…