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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Signal transducer and activator of transcription 6 (STAT6)

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Aliases: STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6

By modifying and activating the transcription factor STAT6, O-GlcNAc transferase promoted the transcription of lineage-defining Pou2f3 in tuft cell differentiation and IL-25 production.
Zhao et al. 2022 Immunity 55: 623-638.e5…

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Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
Zhao et al. 2022 Immunity 55: 623-638.e5
Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement.
Ceponis et al. 2000 J Biol Chem 275: 29132-7

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12/15/2025

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Signal transducer and activator of transcription 6 (STAT6)

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