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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Phosphoinositide 3-kinases (PI3Ks)

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Phosphoinositide 3-kinase (PI3K) is involved in tumor proliferation and survival.
Damodaran et al. 2022 J Clin Oncol 40: 1552-1561

Activation of phosphatidylinositol 3-kinase in response to IL-1 leads to phosphorylation & activation of NF-kB p65/RelA subunit
Sizemore et al. 1999

Class I PI3K is a heterodimer with a regulatory and catalytic subunit.
Damodaran et al. 2022 J Clin Oncol 40: 1552-1561

The catalytic subunit, p110, has four isoforms: alpha, encoded by PIK3CA; [b…

A Case for Phosphoinositide 3-Kinase–(PI3K) Targeted Therapy for Infectious Disease
Adefemi et al. 2020 J. Immunol 205: 3237
Review
Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-kB p65/RelA Subunit
Sizemore et al. 1999
Franklin H. Epstein Lecture: Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
Goncalves et al. 2018 N Engl J Med 379: 2052-2062
Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement.
Ceponis et al. 2000 J Biol Chem 275: 29132-7
Phase II Study of Copanlisib in Patients With Tumors With PIK3CA Mutations: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1F
Damodaran et al. 2022 J Clin Oncol 40: 1552-1561

5/29/2026