Loading…

Medical Research Finder

Legal Notice
Privacy
Terms of Use

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

meRfi® AI Chat

TRPM7

Welcome to meRfi-GM!

Please register to continue your trial period!

meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

(Login)

Navigation

TRPM7 is a TRP channel that also contains an enzymatic kinase domain (hence called chanzyme). It is highly expressed in macrophages.
Schappe et al. 2018 Immunity 48: 59-74

TRPM7 Mediates the Ca Influx Essential for LPS-Induced TLR-4 Endocytosis and Macrophage Activation
Schappe et al. 2018 Immunity 48: 59-74

Lipopolysaccharides (LPS)-mediated macrophage activation is highly dependent on TRPM7. Mice in which Trpm7 is selectively deleted in macrophages resist Lipopolysaccharides (LPS)-induced peritonitis.
Schappe et al. 2018 Immunity 48: 59-74

TRPM7 mediates the LPS-induced Ca2+ increases that are essential for TLR4 end…

References (Sources)

Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation
Schappe et al. 2018 Immunity 48: 59-74
Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis
Desai et al. 2012 Dev. Cell 22: 1149-1162
Potentiation of TRPM7 inward currents by protons
Jiang et al. 2005 J. Gen. Physiol. 126: 137-150

AI Chat

12/16/2025

Chat with our artificial intelligence:

Start chat!

TRPM7

Welcome to meRfi-GM!

Navigation

Contents

References (Sources)

AI Chat

Links