TRPM7

TRPM7 is a TRP channel that also contains an enzymatic kinase domain (hence called chanzyme). It is highly expressed in macrophages.
Schappe et al. 2018 Immunity 48: 59-74

TRPM7 Mediates the Ca Influx Essential for LPS-Induced TLR-4 Endocytosis and Macrophage Activation
Schappe et al. 2018 Immunity 48: 59-74

Lipopolysaccharides (LPS)-mediated macrophage activation is highly dependent on TRPM7. Mice in which Trpm7 is selectively deleted in macrophages resist Lipopolysaccharides (LPS)-induced peritonitis.
Schappe et al. 2018 Immunity 48: 59-74

TRPM7 mediates the LPS-induced Ca2+ increases that are essential for TLR4 endocytosis (and hence IRF3 activation) and nuclear translocation of NFkB.
Schappe et al. 2018 Immunity 48: 59-74

TRPM7 is permeable to Na+, Ca2+, Mg2+, and Zn2+ and has previously been linked to Fas receptor endocytosis
Desai et al. 2012 Dev. Cell 22: 1149-1162

The TRPM7 channel is regulated by several signals relevant to inflammation, including caspase-dependent cleavage and extracellular pH
Jiang et al. 2005 J. Gen. Physiol. 126: 137-150
Desai et al. 2012 Dev. Cell 22: 1149-1162

see also:
Biological effects / Functions & Lipopolysaccharides (LPS)
CD284 (Toll-Like Receptor 4 (TLR-4)) / MYD88 / NFKB signaling pathway