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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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PGE2

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Prostaglandins (PG) are cytoprotective for gastrointestinal epithelium, possibly because they enhance mucosal repair
Blikslager et al. 1997 J. Clin. Invest. 100: 1928–1933

In contrast to inhibition of crypt regeneration, PGE2 accelerates re-establishment of epithelial barrier
Kim et al. 2017a Gastroenterology 152: 616–630
Miyoshi et al. 2017 EMBO J. 36: 5–24
Jain et al. 2018 Cell Host Microbe 24: 353–363

Prostacyclin and PGE2 synergistically restore barrier function in the ileum by the intracellular Ca 2+ and cAMP signaling-dependent mechanisms
Blikslager et al. 1997 J. Clin. Invest. 100: 1928–193…

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Prostaglandin E2 Activates YAP and a Positive-signaling Loop to Promote Colon Regeneration Following Colitis but Also Carcinogenesis in Mice
Kim et al. 2017a Gastroenterology 152: 616–630
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium
Miyoshi et al. 2017 EMBO J. 36: 5–24
Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum
Blikslager et al. 1997 J. Clin. Invest. 100: 1928–1933
Temporal regulation of the bacterial metabolite deoxycholate during colonic repair is critical for crypt regeneration
Jain et al. 2018 Cell Host Microbe 24: 353–363

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