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Cryptococcus neoformans, the most common cause of fungal meningitis and a major pathogen in AIDS, induces a pathogenic type 2 response characterized by pulmonary eosinophilia and alternatively activated macrophages (Allergic inflammation) 3–8
Dang et al. 2022 Nature 608: 161
C. neoformans, a common cause of lethal meningitis in immunocompromised patients, is responsible for $200,000 deaths annually worldwide, mostly in the AIDS population. 1,4
De Giovanni et al. 2023 Immunity 56(7): 1548-1560
Resistance against Cryptococcus neoformans primarily involves immune effector mechanisms and T helper (Th) cells are key players. Whereas IL-12-dependent Th1 responses are protective, [Th2 cells](brain://fzYBEdHxsES6kR…