meRfi®-GM
Bacteroides fragilis Toxin (BFT) / Fragilysin
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Contents
Bacteroides fragilis may stimulate breast cancer metastasis. It secretes Bacteroides fragilis Toxin (BFT) / Fragilysin. This leads to activation of the beta-catenin-Notch1 pathways.
Enterotoxigenic Bacteroides fragilis (ETBF) produces a toxin termed Bacteroides fragilis Toxin (BFT) that causes colitis and has been associated with promoting colon tumorigenesis
Kim et al. 2017 Immu…
References (Sources)
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
- A procarcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates notch and beta-catenin axes.
- Bacteroides fragilis Toxin Induces IL-8 Secretion in HT29/C1 Cells through Disruption of E-cadherin Junctions
- Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island
- The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens