Bacteroides fragilis Toxin (BFT) / Fragilysin

Bacteroides fragilis may stimulate breast cancer metastasis. It secretes Bacteroides fragilis Toxin (BFT) / Fragilysin. This leads to activation of the beta-catenin-Notch1 pathways.
Parida et al. 2021 Cancer Discov 11: 1138-1157

Enterotoxigenic Bacteroides fragilis (ETBF) produces a toxin termed Bacteroides fragilis Toxin (BFT) that causes colitis and has been associated with promoting colon tumorigenesis
Kim et al. 2017 Immunol Rev. 279(1): 90-105

The enterotoxin Bacteroides fragilis Toxin (BFT) / Fragilysin acted as a metalloprotease for cleavage of junctional protein and induction of epithelial-derived Chemokine (C-X-C motif) ligand 8 (CXCL8) / Interleukin-8 (IL-8) synthesis, which were suggested to be involved in the colitogenic ability
Remacle et al. 2014 PLoS One. 9(11):e113896

The human colonic bacterium Enterotoxigenic Bacteroides fragilis (ETBF), which secretes Bacteroides fragilis Toxin (BFT), triggered STAT3 signal transduction pathway in intestinal epithelial cells, induced colitis and dramatically increased the number of colonic tumors
Wu et al. 2009 Nat. Med. 15: 1016