meRfi®-GM
Group 2 ILCs (ILC2)
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Group 2 innate lymphoid cells (ILC2s) are pivotal in the immune system's response to various extracellular pathogens, particularly those affecting the bowel. These cells facilitate critical physiological responses such as vasodilation, increased mucus production, and enhanced macrophage activity. ILC2s are characterized by the expression of phenotypic markers such as CD25+, CD127+, and Thy1.2+, and transcription factors like GATA3 and RAR-related orphan receptor alpha (ROR-alfa).
ILC2s are stimulated by cytokines including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), leading to the secretion of signature cytokines such as IL-4, IL-5, IL-9, IL-13, and amphiregulin (AREG). These cytokines play a crucial role in mediating type 2 inflammatory responses, which are essential for tissue repair and combati…
References (Sources)
- Group 2 Innate Lymphoid Cells Promote Development of T Follicular Helper Cells and Initiate Allergic Sensitization to Peanuts
- IL-33-dependent group 2 innate lymphoid cells promote cutaneous wound healing
- Regulation of Human Innate Lymphoid Cells in the Context of Mucosal InflammationReview
- S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
- The role of helper innate lymphoid cells in cancerReview
- The survival of memory CD4 + T cells within the gut lamina propria requires OX40 and CD30 signals
- Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit