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Dietary interventions have been shown to be effective in preventing chronic metabolic diseases
Larik et al. 2024 Cell Host & Microbe 32(8): 1225
Metabolism is regulated by various factors, and imbalances between energy intake and expenditure can lead to metabolic diseases
Metabolic diseases are widespread worldwide and include diseases resulting from overnutrition, such as obesity or malnutrition, such as kwashiorkor.
Both the immune system and the microbiota contribute to various metabolic diseases.
Metabolic disorders are often accompanied b chronic low-grade inflammation, driven by the activation of various molecular pathways such as STAT3 (signal transducer and activator of transcription 3), IKK (IκB kinase), MMP9 (matrix metallopeptidase 9), MAPK (mitogen-activated protein kinases), COX2 (cyclooxigenase 2), and NF-Kβ (nuclear factor kappa-light-chain-enhancer of activated B cells)