meRfi®-GM
Olfactory epithelium
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Contents
The maximum permissible volume for drug administration via the olfactory epithelium is between 25–200 mL. Although the nasal cavity has a total volume of about 6 cm³, most of the medication administered intranasally is absorbed by the respiratory epithelium (RE) and transported to the circulatory system, thereby reducing the amount that reaches the brain
The olfactory epithelium (OE) covers a small surface area of approximately 5 cm², which is about 3% of the total nasal cavity surface area. This restricts the amount of medi…
References (Sources)
- Anatomical and histological factors affecting intranasal drug and vaccine delivery
- Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
- Direct Drug Transport from the Rat Nasal Cavity to the Cerebrospinal Fluid: the Relation to the Molecular Weight of Drugs
- Formulation strategies for nose-to-brain delivery of therapeutic molecules
- Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
- The Nose Revisited: A Brief Review of the Comparative Structure, Function, and Toxicologic Pathology of the Nasal Epithelium
- Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity