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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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NF kappa B (NFKB) / NFKB Family & Trimethylamine-N-Oxide (TMAO)

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TMAO promotes vascular calcification through activation of NLRP3 inflammasome and NFKB signals, suggesting the potential link between gut microbial metabolism and vascular calcification.
Zhang et al. 2020a Arterioscler Thromb Vasc Biol. 40(3): 751-765

Activation of NFKB signaling was necessary for TMAO to induce inflammatory gene expression in both of these relevant cell types as well as endothelial cell adhesion of leukocytes.
Seldin et al. 2016 J Am Heart Assoc. 5: e002767

Acute TMAO injection at physiological levels was sufficient to induce the same inflammatory markers and activate …

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Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB
Seldin et al. 2016 J Am Heart Assoc. 5: e002767
Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals
Zhang et al. 2020a Arterioscler Thromb Vasc Biol. 40(3): 751-765

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5/29/2026

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NF kappa B (NFKB) / NFKB Family & Trimethylamine-N-Oxide (TMAO)

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