Senescent cells / Cellular senescence

Removal of Senescent Cells by Senolytics, Fall under the Aegis of Senotherapies
Shiels et al. 2019 Biochem Soc Trans 47:1165–72

senescence can be accelerated and induced in cells through different extrinsic as well as intrinsic insults such as oxidative and genotoxic stress, (6,7) oncogenic activation, (8) or irradiation (9)
Sharma & Padwad 2020a

Significantly, alkyl catechols, such as fisetin and quercetin, have been identified as potent senolytic agents, able to induce apoptosis in senescent cells
Missailidis et al. 2016 PLoS ONE 11, e0141738

Senescent cells are cells that stop dividing, accumulate with age, and adversely affect the microenvironment through secretion of pro-inflammatory modulators including cytokines, chemokines, proteases, growth factors, and bioactive lipids, which in turn impact the gut m…