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Senescent cells / Cellular senescence
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Removal of Senescent Cells by Senolytics, Fall under the Aegis of Senotherapies
Shiels et al. 2019 Biochem Soc Trans 47:1165–72
senescence can be accelerated and induced in cells through different extrinsic as well as intrinsic insults such as oxidative and genotoxic stress, (6,7) oncogenic activation, (8) or irradiation (9)
Sharma & Padwad 2020a
Significantly, alkyl catechols, such as fisetin and quercetin, have been identified as potent senolytic agents, able to induce apoptosis in senescent cells
Senescent cells are cells that stop dividing, accumulate with age, and adversely affect the microenvironment through secretion of pro-inflammatory modulators including cytokines, chemokines, proteases, growth factors, and bioactive lipids, which in turn impact the gut m…
References (Sources)
- Cellular Senescence and the Senescent Secretory Phenotype: Therapeutic Opportunities
- Cellular senescence in ageing: From mechanisms to therapeutic opportunities
- Cellular senescence, ageing and disease
- Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
- Mitochondria, immunosenescence and inflammaging: A role for mitokines?
- Telomeres: history, health, and hallmarks of aging
- The interplay between immunosenescence and age-related diseases