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Rapamycin (PI3K-Akt-mTOR) pathway
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Contents
The phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is a fundamental regulator of cell proliferation and survival. Dysregulation in this pathway leads to the development of cancer.
Activation of the PI3K/AKT/ mTOR pathway through PIK3CA mutations or pten gene loss is observed in many human cancers
Accumulating evidence indicates that dysregulation in the PI3K/AKT/mTOR pathway is involved in:
- Cancer initiation
- Cancer progression
- Cancer recurrence
The pathway consists of various signal transducing factors related to cellular events such as:
- Transfor…