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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

G-protein coupled Receptor 41 (GPR41) & Short-chain Fatty Acids (SCFAs)

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Short-chain Fatty Acids (SCFAs) stimulate G-protein coupled Receptor 41 (GPR41) on enteroendocrine cells to the secretion of anorectic gut hormones, such as glucagon-like peptide 1 (GLP-1) and plasma peptide YY (PYY). These hormones reach the portal vein and are involved in [Appetite regulation](brain://tubQ_72WKUCK0-5mgMcVjQ/AppetiteRegulati…

A novel SCFA receptor, the microbiota, and blood pressure regulation
Pluznick 2014 Gut Microbes 5: 202-207
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Samuel et al. 2008 PNAS 105: 16767-16772
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul et al. 2003
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.
Trompette et al. 2014 Nat. Med. 20: 159–166
Microbial short chain fatty acid metabolites lower blood pressure via endothelial G proteincoupled receptor 41
Natarajan et al. 2016 Physiol Genomics 48: 826-834
Microbiota metabolite short-chain fatty acids (SCAFs), GPCR, and inﬂammatory bowel diseases
Sun et al. 2017
The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319

5/29/2026