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Colorectal Cancer (CRC) & Polyamines / Polyamine
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Polyamines / Polyamine, which are derived from the metabolism of amino acids, are primarily carcinogenic at high concentrations
Polyamines promote inflammation and proliferation of colon cancer cells
On the one hand, they reach the tumor cells via the polyamine transporter; on the other hand, the increased expression of ornithine decarboxylase (ODC) in colon cancer cells is linked to increased [polyamine biosynthesis](brain://rr…
References (Sources)
- Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial
- Levels of colorectal ornithine decarboxylase activity in patients with colon cancer, a family history of nonpolyposis hereditary colorectal cancer, and adenomas.
- Polyamines, diamine oxidase, and ornithine decarboxylase activity in colorectal cancer and in normal surrounding mucosa.
- The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response