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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD33 (sialic acid binding Ig-like lectin 3) (Siglec-3)

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CD33 is primarily expressed on cells of the myeloid lineage: Myeloid progenitor cells, Acute myeloid leukemia (AML) blast cells (85-90% of AML cases), Monocytes, Neutrophils (weak expression), Microglia
Bhattacherjee et al. 2021 Mol Neurodegener. 16(1): 19
Molica et al. 2021 Cancers (Basel) 13(13): 3214
Gu et al. 2022 Transl Psychiatry 12(1): 427
Javor et al. 2022 Life (Basel) 12(7): 1094
Olingy et al. 2022 Front Immunol.13: 842653
Tortora et al. 2022 Int J Mol Sci. 23(7): 3629

see also:
[Alzheimer's Disease (AD) & Mi…

References (Sources)

Alzheimer's Disease Risk Variant rs3865444 in the CD33 Gene: A Possible Role in Susceptibility to Multiple Sclerosis
Javor et al. 2022 Life (Basel) 12(7): 1094
CD33 Expression and Gentuzumab Ozogamicin in Acute Myeloid Leukemia: Two Sides of the Same Coin
Molica et al. 2021 Cancers (Basel) 13(13): 3214
Review
CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer
Olingy et al. 2022 Front Immunol.13: 842653
CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role
Tortora et al. 2022 Int J Mol Sci. 23(7): 3629
Peripheral level of CD33 and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study
Gu et al. 2022 Transl Psychiatry 12(1): 427
The CD33 short isoform is a gain-of-function variant that enhances Aβ1-42 phagocytosis in microglia
Bhattacherjee et al. 2021 Mol Neurodegener. 16(1): 19

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CD33 (sialic acid binding Ig-like lectin 3) (Siglec-3)

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