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Cell damage or stress can be triggered by various factors, including tissue injury, radiation, drug treatment, infection, and ischemic shock. These triggers lead to the production of Damage-Associated Molecular Patterns (DAMPs). DAMPs are released into the cytoplasm by disrupted or stressed organelles or into the extracellular space by damaged cells.
DAMPs are recognized by
DAMP-sensing receptors are expressed not only by…