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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Helminth Infections / Helminthiasis & Tuft Cells

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Contents

Epithelial cells secrete chloride to regulate water release at mucosal barriers.

Supports homeostatic hydration.

Critical for the "weep" response in type 2 immune defense against parasitic worms (helminths).

Billipp et al. 2024 Immunity 57(6): 1243-1259

Epithelial tuft cells in the small intestine:
* Sense helminths.

Release cytokines and lipids to activate type 2 immune cells.

Unknown if they regulate epithelial secretion

Billipp et al. 2024 Immunity 57(6): 1243-1259

Tuft cell activation rapidly induced epithelial chloride secretion in the [small intestine](brain://eV4lBJ19WEiPIy46-1cX_Q/…

References (Sources)

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
Gerbe et al. 2016 Nature 529: 226-230
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
Artis et al. 2004 Proceedings of the National Academy of Sciences of the United States of America 101: 13596-13600
Tuft cell acetylcholine is released into the gut lumen to promote antihelminth immunity
Ndjim et al. 2024 Immunity 57(6): 1260-1273
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance
Billipp et al. 2024 Immunity 57(6): 1243-1259
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
Howitt et al. 2016 Science 351: 1329–1333
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
von Moltke et al. 2016 Nature 529: 221-225
Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity
McGinty et al. 2020 Immunity 52: 528-541

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5/29/2026

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