meRfi®-GM
Helminth Infections / Helminthiasis & Tuft Cells
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Epithelial cells secrete chloride to regulate water release at mucosal barriers.
- Supports homeostatic hydration.
- Critical for the "weep" response in type 2 immune defense against parasitic worms (helminths).
Epithelial tuft cells in the small intestine:
* Sense helminths.
- Release cytokines and lipids to activate type 2 immune cells.
- Unknown if they regulate epithelial secretion
Tuft cell activation rapidly induced epithelial chloride secretion in the [small intestine](brain://eV4lBJ19WEiPIy46-1cX_Q/…
References (Sources)
- Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
- RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
- Tuft cell acetylcholine is released into the gut lumen to promote antihelminth immunity
- Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance
- Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
- Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
- Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity