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Genomic instability resulting from DNA damage repair (DDR) deficiencies is a hallmark of cancer and offers significant treatment opportunities. One such DDR defect, homologous recombination deficiency, arises from mutations in critical genes, including BRCA1 and BRCA2. Targeting these DDR defects in Pancreatic ductal adenocarcinoma (PDAC) / Pancreatic cancer is emerging as a promising treatment strategy, with a current focus on BRCA mutations.
BRCA germline mutations are…