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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Deoxyhypusine

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Deoxyhypusine is an unusual amino acid formed by a post-translational modification of the eukaryotic translation initiation factor 5A (eIF5A). This modification is essential for the function of eIF5A and is carried out in two steps:

Synthesis of deoxyhypusine: The enzyme deoxyhypusine synthase (DHS) transfers an amino group from spermidine to a specific lysine residue of Eukaryotic initiation factor 5A (eIF-5A), thereby forming deoxyhypusine

Jeelani & Nozaki 2021 PLoS Pathog. 17(2): e1008909
Wątor et al. 2024 FEBS J. 2024 Jun 23. doi: 10.1111/febs.17207

Hydroxylation…

References (Sources)

Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and differentiation of the human enteric protozoan parasite Entamoeba histolytica
Jeelani & Nozaki 2021 PLoS Pathog. 17(2): e1008909
Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors
D'Agostino et al. 2020 Front Chem. 8: 609942
Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase
Wątor et al. 2024 FEBS J. 2024 Jun 23. doi: 10.1111/febs.17207

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12/17/2025

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Deoxyhypusine

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