meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Deoxyhypusine
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Contents
Deoxyhypusine is an unusual amino acid formed by a post-translational modification of the eukaryotic translation initiation factor 5A (eIF5A). This modification is essential for the function of eIF5A and is carried out in two steps:
- Synthesis of deoxyhypusine: The enzyme deoxyhypusine synthase (DHS) transfers an amino group from spermidine to a specific lysine residue of Eukaryotic initiation factor 5A (eIF-5A), thereby forming deoxyhypusine
- Hydroxylation…
References (Sources)
- Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and differentiation of the human enteric protozoan parasite Entamoeba histolytica
- Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors
- Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase