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CD25 also known as Interleukin-2 receptor alfa chain (IL-2RA). This is the high-affinity component of the Interleukin-2 (IL-2) Receptor, which also includes CD122 (Interleukin-2 Receptor Subunit Beta Chain (IL2RB)) and the Interleukin-2 Receptor Gamma Chain (IL2RG). It is upregulated by activated T cells and is constitutively expressed by CD4 + CD25 + high CD45RA - CD45 RO + CD127 low HLA-DR - CD95 + CTLA4 + Ki67 + ICOS +/- FOXP3 + high Effector Regulatory T Cells
Murphy et al. …