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The connection between Caspase-11 (mice) and Pyroptosis is primarily observed through the non-canonical inflammasome pathway, which is distinct from the canonical inflammasome pathway that involves caspase-1.
Caspase-11 (mice) is activated by cytosolic Lipopolysaccharides (LPS). It then cleaves Gasdermin D (GSDMD) after several downstream steps. This forms the pore-forming N-terminal fragment (GSDMD-N Domain). GSDMD-N inserts into the cell membrane. The cell…