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Chemotherapy-induced cardiotoxicity refers to heart damage resulting from cancer treatment, particularly the use of specific chemotherapy drugs or targeted therapy drugs, as well as chest radiation therapy. This condition can manifest as functional or structural cardiac injury and includes a range of cardiac problems, including myocardial injury, left ventricular dysfunction (LVD), cardiomyopathy, and heart failure (HF). It also affects other cardiac structures, such as the pericardium, valves, and coronary arteries.

Chemotherapy-induced cardiotoxicity can be classified into acute or subacute types and may be due to various mechanisms, including [reactive oxygen species…