Loading…
Please register to continue your trial period!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
In intestinal epithelial cells, Nuclear Factor Interleukin-3 Regulated (NFIL3), a basic leucine zipper transcription factor controlled by the circadian clock (; ), governs the rhythmic expression of genes that regulate lipid absorption, processing, and storage ().
The microbiota induces epithelial Nuclear Factor Interleukin-3 Regulated (NFIL3) expression through the circadian clock factor REV-ERB alfa and a DC-ILC3 signaling relay. Consequently, mice lacking epithelial cell NFIL3 absorb less lipid and have a…