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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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2-Arachidonoylglycerol (2-AG)

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2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the Cannabinoid receptor 1 (CB1) and the primary endogenous ligand for the Cannabinoid receptor 2 (CB2)
Stella et al. 1997 Nature 388 (6644): 773-8
Sugiura et al. 1999 The Journal of Biological Chemistry 274 (5): 2794-801

It is present at relatively high levels in the central nervous system, with cannabinoid neuromodulatory effects.
Sugiura et al. 1999 The Journal of Biological Chemistry 274 (5): 2794-801

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A second endogenous cannabinoid that modulates long-term potentiation
Stella et al. 1997 Nature 388 (6644): 773-8
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds
Sugiura et al. 1999 The Journal of Biological Chemistry 274 (5): 2794-801

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2-Arachidonoylglycerol (2-AG)

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