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Biosynthetic gene clusters (BGCs)

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Contents

= genes responsible for the biosynthesis of a natural product, colocalized in a genomic region
Zdouc et al. 2023 Trends Pharmacol Sci 44(8): 532

Bioinformatics studies have demonstrated that there can be upwards of 30 biosynthetic gene clusters (BGCs), with most encoding for unknown NPs
Mukherjee et al. 2017 Nat. Biotechnol. 35: 676