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NOD-like receptors (NLRs)
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Contents
Human NOD-like receptors (NLRs) are composed of 22 distinct members; mouse NOD-like receptors (NLRs) of 34 distinct members.
Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are cytosolic pattern recognition receptors that detect various triggers. Activation of specific NLRs leads to signaling cascades and the formation of inflammasomes, which induce inflammatory cytokine maturation and cell death. Some NLRs and inflammasomes are part of larger cell death complexes called PANoptosomes. This review explores the evolut…
References (Sources)
- ADAR1 restricts ZBP1-mediated immune response and panoptosis to promote tumorigenesis
- Cryopyrin activates the inflammasome in response to toxins and ATP
- Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
- Identification of the PANoptosome: A molecular platform triggering pyroptosis, apoptosis, and necroptosis (panoptosis)
- Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
- NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion
- NOD-Like Receptors in Infection, Immunity, and Diseases