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Human NOD-like receptors (NLRs) are composed of 22 distinct members; mouse NOD-like receptors (NLRs) of 34 distinct members. However, many NLRs remain only superficially characterized, with a lack of deep mechanistic insight. This gap in understanding affects approximately half of the NLR family, making it challenging to define their clinical relevance and therapeutic potential.
There are three subgroups of NLRs (NOD-like receptors) based on biological function:
The Inflammasome-forming NLRs are the most intensively studied and includes NLRs that form an inflammasome with the [adaptor …