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Here, we report the development of PROT3EcT, a suite of commensal Escherichia coli engineered to secrete proteins directly into their surroundings.
These bacteria comprise three modular components: a modified bacterial protein secretion system, the associated regulatable transcriptional activator, and a secreted therapeutic payload.
Gut native E. coli are genetically tractable and can serve as a chassis for transgene delivery (e.g., bile salt hydrolase) (Escherichia coli EcAZ-2 BSH)
[Engineered native E. coli (Ec…