Glioblastoma multiforme (GBM) / Glioblastoma & Drugs/Treatments

Glioblastoma, isocitrate dehydrogenase wildtype (IDHwt), remains an incurable disease despite considerable research effort. The current standard of care since 2005 comprises maximal safe resection followed by radiation with concurrent and adjuvant temozolomide; more recently, the addition of tumor treating fields was approved in the newly diagnosed and recurrent disease settings.
Fisher & Adamson 2021 Biomedicines 9(3): 324
Nelson & Dietrich 2023 Expert Opinion on Investigational Drugs 32(10): 921-930

Unfortunately, hundreds of trials, including of agents effective in systemic malignancy, have not drastically changed management of glioblastoma. This may reflect unique resistance mechanisms and highlights a need for multimodality treatments beyond surgery, radiation, and conventional chemotherapy.
Nelson & Di…